Sunday, December 19, 2010

Public Health genomics

I just read about a machine that is to cost $50,000 which using a disposable $250 chip will be able to sequence 10 to 20 million base pairs of the human genome in a few hours. According to Technology Review, the cost of the disposable chip can be expected to come down relatively quickly.

We read about personalized medicine in which genomic and other information can be used to select treatment protocols specific to the patient, including to the specific genetic aspects of the person's disease and the person's immune system. I have also read that one of the reasons that European diseases introduced to the Americas proved so disastrous was that the Native American populations were relatively genetically homogeneous, with the total population of the continents descended from relatively small immigrant populations relatively recently introduced from Asia. The theory is that the infectious agent population that evolved in an infected person would be especially virulent in the next infected person because of the average similarity in the immune systems of randomly selected people from the Native American population.

I wonder if there might be an intermediate stage from our current average medicine and personalized medicine to "community medicine" in which public health officials would sequence key portions of the genomes of a sample of people in a community to tailor health services to the average immunological characteristics of the community and the average risk of genetically based diseases.

No comments: