Do cities have characteristic moods?

Orhan Pamuk in his book Istanbul: Memories and the City describes a mood as characteristic of his city, contrasting that relatively sad mood with the moods that have been described for other cities.

Now the New Scientist has an article suggesting that the immune system may affect the mind, and thus that the history of infections and lack of infections may have long term effects on ones mental state, including mood. Perhaps the endemic and epidemic disease pattern of a city, by influencing patterns of immunological system status, may tend to produce a mood characteristic of a city.

I suspect that there are other things that affect the mood of a city. For example, Geneva is overcast for months at a time, and people have observed that during those winter months the mood of the city changes. Similarly, people in one city may be genetically happier than those in another city. Who knows?

Incidentally, Nobel Literature Prize winner Pamuk has written a very nice book in Istanbul: Memories and the City.