Two new vaccines aimed at preventing childhood diarrhea caused by rotavirus could cut severe cases of that ailment in half if widely used. Rotavirus is a major cause of diarrheal dealth in poor countries. The results are due for publication today in the New England Journal of Medicine:
* Efficacy and Safety of a G1P[8] Rotavirus Vaccine
* Human–Bovine Reassortant Rotavirus Vaccine
The vaccines produced a strong immune response that kept many children from getting sick and protected others enough to keep them out of the hospital. And the studies -- which enrolled 131,263 children, the largest vaccine tests since the polio trials of the 1950s -- offered reassuring findings about the safety of the vaccines. That was a critical issue because a similar vaccine was withdrawn from the market six years ago after apparently injuring some children.
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